Turmesac® is a novel, synergistic phytochemical composition made from turmeric rhizome, Curcuma longa. Unlike conventional turmeric ingredients that focus primarily on isolated curcumin, Turmesac® retains a broader matrix of water-extractable turmeric phytochemicals, curcuminoids and naturally occurring turmeric oil.
This full-spectrum approach is designed to allow multiple turmeric-derived constituents to work together. Turmesac® has been investigated in preclinical models for inflammatory response, antioxidant protection, hepatoprotective activity, bioavailability and cellular health. It is designed for manufacturers developing dietary supplements, functional beverages and wellness foods.
No acute toxic symptoms or mortality were reported at doses up to 2,000 mg/kg body weight. The 28-day study evaluated doses of 250, 500 and 1,000 mg/kg body weight and reported no Turmesac®-related toxic effects across the assessed parameters.
How the complete phytochemical matrix works
Explore the proposed roles of turmeric polysaccharides, curcuminoids and turmeric oil in antioxidant activity, inflammatory signalling, cellular uptake and tissue protection.
Explore the Mechanism →Evidence across cellular and animal models
Review published studies examining inflammatory cytokines, oxidative stress, liver markers, edema models and cellular viability.
View the Research →Evaluated for acute and repeated-dose safety
Discover the acute and 28-day sub-acute toxicology studies, including clinical observations, organ assessment, histopathology, hematology and biochemical parameters.
Review Safety Data →Designed for multiple delivery formats
Explore formulation options for ready-to-mix beverages, wellness shots, gummies, chewables, capsules, tablets and other functional products.
View Applications →Turmeric Polysaccharides
01Water-extractable phytochemicals
Contribute to the full-spectrum turmeric matrix and have been investigated for antioxidant and free-radical-scavenging properties.
Curcumin
02Curcuminoid polyphenol
The principal turmeric curcuminoid, widely studied for its interaction with oxidative and inflammatory pathways.
Demethoxycurcumin
03Curcuminoid
A naturally co-occurring turmeric compound that complements the broader curcuminoid spectrum.
Bisdemethoxycurcumin
04Curcuminoid
Supports the complete curcuminoid profile rather than relying on a single isolated molecule.
Turmeric Oil and Turmerones
05Volatile phytochemicals
Provides lipophilic turmeric constituents, including alpha-turmerone and beta-turmerone, within the full-spectrum composition.
The research literature describes turmeric rhizome as containing curcumin, demethoxycurcumin, bisdemethoxycurcumin, dihydrocurcumin and volatile oils that include alpha-turmerone, beta-turmerone and monoterpenes.
Spray-dried turmeric water extract 95% · Curcuminoids 3% · Turmeric oil 2%
Turmesac® significantly reduced edema in croton oil and histamine-induced animal models. At 500 mg/kg, inhibition of croton oil-induced ear edema reached 58.65% at two hours and 57.25% at four hours.
In LPS-stimulated RAW 264.7 macrophages, Turmesac® reduced the measured fluorescence intensity of IL-8 from 50.49 to 19.63 and IL-12 from 68.94 to 15.79.
Turmesac® demonstrated DPPH free-radical-scavenging activity and reduced oxidative stress markers in hydrogen peroxide-stressed liver cell models.
In H₂O₂-stressed HepG2 cells, incubation with 50 µg/ml Turmesac® reduced mean intracellular ROS fluorescence from 52.5 to 14.43.
In a paracetamol-induced liver toxicity model, Turmesac® reduced elevated SGOT, SGPT and bilirubin while improving antioxidant enzyme levels and liver histology.
Turmesac® produced concentration-dependent cytotoxicity in HeLa cervical adenocarcinoma cells, with an IC₅₀ of 115.12 µg/ml. At this concentration, the study reported apoptosis and cell-cycle effects. These findings remain preclinical and require human validation.
In an in-vivo study, Turmesac® was evaluated at 250 and 500 mg/kg in croton oil-induced ear edema and histamine-induced paw edema models. The 500 mg/kg dose produced 58.65% inhibition of ear edema at two hours and 57.25% inhibition at four hours. Significant reductions were also observed in the histamine-induced paw edema model.
Read the Published Anti-Inflammatory Study →An overview of the Turmesac® composition, research and applications.
Published in-vitro and in-vivo studies covering inflammation, liver protection, antioxidant activity and cellular health.
Composition, quality parameters, microbiology and formulation guidance.
Acute and 28-day sub-acute toxicology data.
Recommendations for beverages, shots, gummies, capsules and tablets.
Visual explanations of the phytochemical matrix and preclinical findings.
Star Hi Herbs is an Indian manufacturer, supplier and developer of standardized botanical extracts and branded nutraceutical ingredients. The company has been innovating since 2004 and provides technical specifications, stability information, formulation support, samples, regulatory documentation and commercial supply-chain assistance for product development.
Turmesac® is manufactured and registered by Star Hi Herbs in Karnataka, India.
Visit Star Hi Herbs →Speak with our technical and commercial teams about samples, specifications, documentation and formulation support.
Star Hi Herbs Pvt. Ltd.
Karnataka, India
